通过碳二亚胺法将精氨酸-甘氨酸-天冬氨酸(RGD)接枝到羟基磷灰石(HA)颗粒表面, 增强HA颗粒识别细胞的功能, 然后将其均匀地分布于左旋聚乳酸 (PLLA) 中制备多孔复合材料, 分别用XPS和SEM等对HA颗粒和多孔复合材料进行了表征。结果表明: RGD成功地接枝到了HA颗粒表面, 多孔复合材料中RGD功能化的HA颗粒是纳米尺寸的, 且分布均匀; RGD功能化HA/PLLA多孔复合材料的细胞粘附率从普通HA/PLLA多孔复合材料的37.21%提高到了69.11%。
所属栏目
试验研究黑龙江省科技厅青年科学基金资助项目(Q07C308)
收稿日期
2010/12/262011/9/26
作者单位
杨春莉:哈尔滨商业大学轻工学院, 哈尔滨 150076
杨春瑜:哈尔滨商业大学食品工程学院, 哈尔滨 150076
盖艳娇:哈尔滨商业大学轻工学院, 哈尔滨 150076
赵智臻:厦门大学化学化工学院, 厦门 361005
刘壮:哈尔滨商业大学轻工学院, 哈尔滨 150076
王君:哈尔滨商业大学轻工学院, 哈尔滨 150076
备注
杨春莉(1973-), 女, 黑龙江佳木斯人, 讲师, 博士。
引用该论文:
YANG Chun-li,YANG Chun-yu,GE Yan-jiao,ZHAO Zhi-zhen,LIU Zhuang,WANG Jun.Preparation and Characterization of RGD-HA/ PLLA Porous Composite[J].Materials for mechancial engineering,2012,36(1):45～47
杨春莉,杨春瑜,盖艳娇,赵智臻,刘壮,王君.RGD功能化HA/PLLA多孔复合材料的制备和表征[J].机械工程材料,2012,36(1):45～47
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